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目的探讨鼠双微体2(Mdm2)蛋白和P53蛋白在宫颈病变中的表达及其相关性的研究。方法应用免疫组化方法检测Mdm2和P53蛋白在62例宫颈鳞癌,20例宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN),12例慢性宫颈炎中的表达。结果宫颈鳞癌组织中Mdm2和P53蛋白阳性表达率显著高于CIN组和慢性宫颈炎组(P<0.05),Mdm2和P53蛋白在CIN组和慢性宫颈炎组中的阳性表达均无统计学意义(P>0.05);宫颈鳞癌中Mdm2蛋白的阳性表达与病理分级、临床分期、淋巴结转移密切相关(P<0.05),P53的阳性表达与临床分期密切相关(P<0.05);Mdm2和P53在宫颈鳞癌中的表达无相关关系(P>0 05)。结论 Mdm2和P53在宫颈鳞癌发生和发展中起重要作用;Mdm2可能作为判断宫颈鳞癌预后的指标。
Objective To investigate the expression of Mdm2 protein and P53 protein in cervical lesions and their correlation. Methods The expression of Mdm2 and P53 in 62 cases of cervical squamous cell carcinoma, 20 cases of cervical intraepithelial neoplasia (CIN) and 12 cases of chronic cervicitis were detected by immunohistochemistry. Results The positive rates of Mdm2 and P53 protein in cervical squamous cell carcinoma tissues were significantly higher than those in CIN and chronic cervicitis groups (P <0.05). The positive expressions of Mdm2 and P53 protein in CIN and chronic cervicitis groups were not statistically significant (P> 0.05). The positive expression of Mdm2 in cervical squamous cell carcinoma was closely related to the pathological grade, clinical stage and lymph node metastasis (P <0.05). The positive expression of P53 was closely related to clinical stage (P < In cervical squamous cell carcinoma there was no correlation (P> 0.05). Conclusions Mdm2 and P53 play an important role in the occurrence and development of cervical squamous cell carcinoma. Mdm2 may be used as an index to evaluate the prognosis of cervical squamous cell carcinoma.