利福平与异烟肼联合用药所致的有害反应(亦称药物不良反应,简称ADR),主要表现为对肝脏的损害。有害反应的毒理在于异烟肼在肝内被水解成乙酰肼,乙酰肼藉细胞色素P_(450)的各种功能的氧化酶系统,进而代谢成反应性亲电子的中间产物,再与肝组织大分子结合形成共价键而造成肝损害。 Rifampicin and isoniazid combination drug-induced adverse reactions (also known as adverse drug reactions, referred to as ADR), mainly manifested as damage to the liver. Toxicology of harmful reactions is that isoniazid in the liver is hydrolyzed into acetylhydrazine, acetylcholine by cytochrome P_ (450) of the various functions of the oxidase system, and then metabolized into reactive electrophilic intermediates, and then with the liver Tissue macromolecules combine to form covalent bonds and cause liver damage.