HCC易发生早期转移 ,MMPs与HCC浸润转移密切相关 ,过去对MMPs作用的理解主要局限在其能降解ECM ,去除肿瘤转移的机械性屏障。近来研究表明MMPs还可通过影响多种生长因子活性 ,水解蛋白质释放某些生物活性物质在肿瘤发展中起作用。对MMPs及其抑制剂的研究不仅可为肿瘤治疗提供新靶点 ,还可作为肿瘤侵袭转移与预后的重要指征。 HCC is prone to early metastasis, MMPs and HCC infiltration and metastasis are closely related to the past understanding of the role of MMPs confined to its ability to degrade ECM, removal of the mechanical barrier to tumor metastasis. Recent studies have shown that MMPs can also play a role in tumor development by affecting the activity of various growth factors and hydrolyzing proteins to release certain biologically active substances. The study of MMPs and its inhibitors not only can provide a new target for tumor treatment, but also can be used as an important indicator of tumor invasion and metastasis and prognosis.