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目的比较10 d序贯疗法与传统三联疗法根治幽门螺杆菌(Hp)的疗效与安全性。方法选取85例1月内14C尿素呼气试验阳性或者胃镜Hp实验阳性病例,随机分为两组:治疗组前5 d予奥美拉唑、阿莫西林,后5 d予奥美拉唑、替硝唑、克拉霉素治疗;对照组予奥美拉唑加阿莫西林、克拉霉素治疗10 d。疗程结束1月后行14C尿素呼气试验检测。结果1月后疗程结束时,治疗组总有效率97.6%,对照组总有效率73.3%,两组疗效比较有非常显著性差异(P<0.01);治疗组14C尿素呼气试验转阴率为95.2%,对照组转阴率为76.7%,两组Hp转阴率比较具有显著性差异(P<0.05)。结论10 d序贯疗法治疗Hp的根治率较传统三联疗法高,且副作用少,易耐受,安全可靠。
Objective To compare the efficacy and safety of 10-day sequential therapy with traditional triple therapy in the treatment of Helicobacter pylori (Hp). Methods A total of 85 cases of positive cases of 14C urea breath test or gastroscope Hp test in January were randomly divided into two groups: omeprazole and amoxicillin in the first 5 days in the treatment group and omeprazole in the fifth day after the treatment, Tinidazole, clarithromycin treatment; the control group to omeprazole plus amoxicillin, clarithromycin treatment for 10 days. After the end of the course of 14C urea breath test. Results At the end of 1 month after treatment, the total effective rate was 97.6% in the treatment group and 73.3% in the control group. There was significant difference between the two groups (P <0.01). The conversion rate of 14C urea breath test in the treatment group was 95.2% in the control group, and 76.7% in the control group. There was significant difference between the two groups (P <0.05). Conclusions The 10-day sequential therapy for Hp has a higher cure rate than traditional triple therapy and has few side effects and is easily tolerated and safe.