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研究了低(1mg/kg/d)、中(5mg/kg/d)、高(25mg/kg/d)三个剂量组全氟辛酸(Perfluorooctanoic acid,PF OA)致小鼠肝脏脂质过氧化损伤的作用。结果发现,PF OA能抑制小鼠体重的增长,对肝组织造成一定的脂质过氧化损伤。各组小鼠出现不同程度的体重增长缓慢甚至减轻,中、高剂量组出现明显的减轻(P<0.01);低、中、高剂量组肝脏系数,均明显高于对照组(P<0.01);与对照组相比,各剂量组的肝组织中MDA、NO及LDH含量明显增高,SOD、SDH及GSH-Px活性均明显降低(P<0.05)。
To study the effects of perfluorooctanoic acid (PFOA) on liver lipid peroxidation in mice at low (1mg / kg / d), medium (5mg / kg / d) and high (25mg / effect. The results showed that, PF OA can inhibit the growth of mice, causing some lipid peroxidation damage to liver tissue. (P <0.01). The liver coefficient of low, medium and high dose groups were significantly higher than that of the control group (P <0.01) Compared with the control group, the contents of MDA, NO and LDH in the liver tissue of each dose group were significantly increased, and the activities of SOD, SDH and GSH-Px were significantly decreased (P <0.05).