目的提高对尼曼匹克病的认识。方法报道3例尼曼匹克病的发病及诊断经过,并复习文献。结果 3例尼曼匹克病均出现肝脾肿大、不同程度的贫血以及肝功能损害,骨髓检查发现尼曼-匹克细胞而确诊。结论尼曼匹克病是少见疾病,临床有疑似病例时应尽快完善骨髓检查。 Objective To raise awareness of Niemann Pick disease. Methods The incidence and diagnosis of 3 cases of Niemann-Pick disease were reported, and the literature was reviewed. Results All three patients with Niemann-Pick disease developed hepatomegaly and splenomegaly, varying degrees of anemia and liver damage. Niemann-Pick cells were confirmed by bone marrow examination. Conclusion Niemann-Pick disease is a rare disease, bone marrow examination should be completed as soon as possible when there are suspected cases of clinical.