有关金属硫蛋白与肿瘤的研究正日益受到重视。已有的资料显示金属硫蛋白可能参与了某些肿瘤的发生、发展过程 ,并且与某些肿瘤细胞的分化成熟以及细胞凋亡等生物学行为有关。尤其引人注目的是 ,金属硫蛋白在肿瘤组织中的表达是肿瘤对亲电性化疗药产生耐药的内在机制之一。本文拟就金属硫蛋白与肿瘤关系的研究进展综述如下。 Research on metallothionein and tumors is increasingly receiving attention. The available data show that metallothionein may be involved in the occurrence and development of certain tumors, and is related to the biological behaviors of the differentiation and maturation of certain tumor cells and apoptosis. Particularly striking is that the expression of metallothionein in tumor tissues is one of the intrinsic mechanisms of tumor resistance to electrophilic chemotherapeutic agents. This article outlines the research progress of the relationship between metallothionein and tumors as follows.