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产生β-内酰胺酶是细菌对β-内酰胺类抗生素耐药的主要机制,新一代β-内酰胺类抗生素在临床上的大量应用,致使革兰氏阴性细菌产生超广谱β-内酰胺酶(Extended Spectrum β-Lactamase,ESBLs)。该类酶由质粒介导,可在同一种属和不同种属酰胺酶菌之间转移播散,造成院内感染爆发流行,为感染控制和治疗带来严重困难。医务人员对此应予以高度警觉,掌握正确检测、预防或控制这一问题的方法。
Producing β-lactamase is the main mechanism of bacterial resistance to β-lactam antibiotics, a new generation of β-lactam antibiotics in large numbers of clinical applications, resulting in Gram-negative bacteria produce extended spectrum β-lactam Enzymes (Extended Spectrum β-Lactamase, ESBLs). The enzyme-mediated by the plasmid, in the same genus and different species of amidase bacteria spread between disseminated, resulting in outbreaks of nosocomial infections, infection control and treatment of serious difficulties. Medical staff should be highly vigilant about this and have the means to correctly detect, prevent or control this problem.