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急性有机磷中毒(acute organophosphoms pesticides poisoning,AOPP)是我国的常见病和多发病,约占急性中毒的70%~80%,尤其是广大农村,随着农药的广泛使用,其发生率仍在增加。其特点是发病急、变化快、病死率高。该病的发病原因和机制是有机磷农药进入人体后和血清胆碱酯酶(ChE)结合,形成磷酸化ChE,抑制ChE活性,特别是乙酰胆碱酯酶(AChE)的活性,使AChE失去分解乙酰胆碱的能力,导致乙酰胆碱大量积蓄,使胆碱能神经受到持续冲动,导致先兴奋后衰竭的一系列毒蕈碱样、烟碱样和中枢神经系统等症状。
Acute organophosphorus pesticides poisoning (AOPP) is a common and frequently-occurring disease in China accounting for about 70% -80% of acute poisoning, especially in the vast rural areas. With the widespread use of pesticides, the incidence of AOPP is still increasing . It is characterized by acute onset, rapid change, high mortality. The pathogenesis and mechanism of the disease is organophosphorus pesticide into the human body and serum cholinesterase (ChE) to form phosphorylated ChE, inhibition of ChE activity, especially acetylcholinesterase (AChE) activity, AChE loss of decomposition of acetylcholine Of the capacity, resulting in a large number of accumulation of acetylcholine, the cholinergic nerve sustained impulses, leading to failure of the first excited after a series of muscarinic, nicotinic and central nervous system and other symptoms.