糖尿病和肥胖的发生率逐年增加,肥胖是2型糖尿病最主要的风险因素之一。近些年的研究表明,糖尿病患者的体质量与死亡率间的关系较为复杂。体质量指数在正常范围内的糖尿病患者,其死亡率可能较超重或肥胖糖尿病患者更高,这一发现被称为肥胖悖论。本文整理肥胖悖论有关的临床研究结果,简要综述其可能的影响因素及临床意义。 The incidence of diabetes and obesity is increasing year by year. Obesity is one of the most important risk factors for type 2 diabetes. In recent years, studies have shown that the relationship between body mass and mortality in diabetic patients is more complicated. Diabetes, whose body mass index is within the normal range, may have a higher mortality rate than those who are overweight or obese, a finding called obesity paradox. This article organizes the clinical research results related to obesity paradox, briefly summarizes its possible influencing factors and clinical significance.