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制备并用UV、循环伏安(CV)和NMR法研究了NAMI(新抗肿瘤转移抑制剂,trans-[RuCl4(DMSO)(imidazole)]Na·2DMSO)衍生物trans-[RuCl4(DMSO)(2-MeIm)]Na·2DMSO(2-MeIm=2-甲基咪唑,化合物1)和trans-[RuCl4(DMSO)-(N-EtIm)]Na·2DMSO(N-EtIm=N-乙基咪唑,化合物2)的水解机理-动力学、溶液稳定性和电化学性质.化合物1和化合物2与NAMI相似,在pH 7.40的缓冲溶液中发生两步脱氯水解反应(I氯水解及II氯水解)(分步反应);在酸性溶液(pH 5.00)中脱DMSO水解.通过线性拟合得到各水解反应速率常数kobs及半衰期t1/2.结果表明化合物在酸性溶液中的稳定性相对较高.在NAMI衍生物咪唑环的N位引入乙基比在2位引入甲基生成的化合物稳定.含氮配体相同时,NAMI-A(新抗肿瘤转移抑制剂,A:该系列中的第一个化合物,trans-[RuCl4(DMSO)(imidazole)][Himidazole])衍生物略比相应的NAMI衍生物稳定.
The NAMI (trans-[RuCl4 (imidazole)] Na · 2DMSO derivative trans- [RuCl4 (DMSO) (2) was prepared and characterized by UV, cyclic voltammetry (MeIm = 2-methylimidazole, compound 1) and trans- [RuCl4 (DMSO) - (N-EtIm)] Na · 2DMSO (N-EtIm = N- ethylimidazole, Compound 2) hydrolysis mechanism - kinetics, solution stability and electrochemical properties.Compound 1 and 2 similar to NAMI, a two-step dechlorination hydrolysis reaction (I chlorine hydrolysis and II chlorine hydrolysis) in a buffer solution pH 7.40, (Stepwise reaction); hydrolysis of DMSO in acidic solution (pH 5.00), hydrolysis rate constant kobs and half-life t1 / 2 of each hydrolysis reaction were obtained by linear fitting.The results showed that the stability of the compound in acidic solution was relatively high The introduction of the N-position of the imidazole ring of the NAMI derivative into the ethyl group is more stable than the introduction of the methyl group at position 2. NAMI-A (a new antitumor metastasis inhibitor, A: the first in the series The compound, trans- [RuCl4 (DMSO) (imidazole)] [Himidazole] derivative is slightly more stable than the corresponding NAMI derivative.