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目前应用细胞毒药物治疗人类肿瘤大都依赖综合性化学治疗—综合使用几种药物产生协同的效应以达到杀死全部肿瘤细胞。在最近一次会议(1980年5月28日～31日在加州举行的美国肿瘤研究协会年会)中有几篇报道以相似的理由认为,“综合性化学预防”(“Combin-ation chemoprevention”)对于发展预防肿瘤用的非细胞毒药物颇具重要性,那就是在恶性阶段的前期阻断或逆转恶性增生的发展。最近在了解和控制肿瘤促进方面的发展是特别惊人的。威斯康辛大学A.K.Verma 和R.K.Bo-ntwell 在应用小鼠皮肤致癌的传统两阶段模型[以碳氢化合物DMBA 为激发剂和法波酯的
At present, the application of cytotoxic drugs to treat human tumors mostly depends on comprehensive chemotherapy - a combination of several drugs to produce a synergistic effect to kill all tumor cells. In a recent report (annual meeting of the American Association for Cancer Research held in California from May 28th to 31st, 1980), there were several reports that considered “combination chemoprevention” for similar reasons. The importance of developing non-cytotoxic drugs for the prevention of cancer is to block or reverse the development of malignant hyperplasia in the early stage of the malignant stage. The recent development in understanding and controlling tumor promotion is particularly alarming. A.K. Verma and R.K.Bo-ntwell, University of Wisconsin, used a traditional two-stage model of mouse carcinogenesis [using hydrocarbon DMBA as an activator and faraveryl ester