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目的探讨更昔洛韦治疗儿童传染性单核细胞增多症(IM)的疗效。方法采用病例对照方法,将26例IM患儿随机分为α-干扰素(IFN-α)组(对照组)10例和更昔洛韦(GCV)组(治疗组)16例,在一般对症治疗基础上,IFN-α组用IFN-α100万U/d,肌肉注射,疗程5d,GCV组用GCV 10mg/(kg.d)加5%葡萄糖100~200m l静脉滴注(>1h),疗程5d。对总有效率、显效率及患儿对药物的耐受性等进行观察。结果治疗后GCV组退热和咽峡炎好转平均时间均较IFN-α组明显缩短;GCV组/IFN-α组肿大的淋巴结、肝脏脾脏缩小一半所需平均时间差异无统计学意义;WBC、异型淋巴细胞、CK-MB及肝功能恢复正常例数两组差异无统计学意义。GCV组显效率[62.5%(10/16)]高于IFN-α组(30%),但组间总有效率[93.7%(15/16)和80.0%(8/10)]差异无统计学意义。在本组患儿中短期使用GCV未引起WBC降低,且对PLT和血清Cr值均无影响。结论GCV组使IM部分临床症状、体征恢复正常所需时间短于IFN-α组,虽然GCV与IFN-α对IM的总有效率无明显差异,但GCV组的显效率明显高于IFN-α组,且短期使用GCV治疗小儿IM安全有效。
Objective To investigate the efficacy of ganciclovir in the treatment of childhood infectious mononucleosis (IM). Methods Twenty-six patients with IM were randomly divided into interferon-alpha (IFN-α) group (control group) and ganciclovir (GCV) group (treatment group) On the basis of treatment, IFN-α group was treated with IFN-α 1 million U / d intramuscularly for 5 days. GCV group was treated with GCV 10 mg / (kg · d) plus 5% glucose 100-200 ml for intravenous infusion (> 1 hour) Course of treatment 5d. The total effective rate, markedly effective and children with drug resistance were observed. Results After treatment, the average time of antipyretic and angina improved in GCV group was significantly shorter than that in IFN-α group. There was no significant difference in the mean time between GCV group and IFN- , Atypical lymphocytes, CK-MB and normal liver function recovery cases no significant difference between the two groups. (62.5%, 10/16) in the GCV group was higher than that in the IFN-α group (30%), but there was no statistical difference in the total effective rate between the groups (93.7% (15/16) and 80.0% (8/10) Significance of learning. In this group of children in the short-term use of GCV did not cause WBC decreased, and no effect on PLT and serum Cr values. Conclusions GCV group is shorter than IFN-α group in clinical symptoms and signs of IM. Although the total effective rate of GCV and IFN-α has no significant difference, the effective rate of GCV group is obviously higher than that of IFN-α Group, and short-term use of GCV treatment of children with safe and effective IM.