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单核细胞增多性李司忒氏菌已日益成为中枢神经系统感染常见的病原菌。作者报道了11例诊断为该菌感染的3例脑膜炎或脑膜脑炎和1例脑脓肿病例。4例均因肾功能衰竭接受肾移植和使用硫唑嘌呤及强的松后出现灶性神经系统症状和/或精神症状,血和脑脊液培养有李司忒氏菌生长。其中2例分别死于肾功能衰竭、胃肠道大出血。文献中,大多数李司忒氏菌感染患者有淋巴网状系统疾病(何杰金氏病、淋巴瘤等)、肾移植或正在使用免疫抑制剂的病史。作者认为此病在肾移植病人中多见,是因其对李司忒氏菌感染具易感性。泌尿生殖道手术增加了李司忒氏菌感染机会。化疗和原有基础性疾病能诱发免疫功能不全。
Listeria monocytogenes has increasingly become a common pathogen of central nervous system infections. The authors reported 11 cases of meningitis or meningoencephalitis and 1 case of brain abscess diagnosed as having the bacterium. All 4 patients developed focal neurological symptoms and / or psychiatric symptoms after renal transplantation due to renal failure and azathioprine and prednisone. Listeria monocytogenes was cultured in blood and cerebrospinal fluid. Two of them died of renal failure and gastrointestinal bleeding respectively. In the literature, most patients with Listeria infection have a history of lymphatic system diseases (Hodgkin’s disease, lymphomas, etc.), kidney transplants or immunosuppressants being used. The authors believe that the disease more common in kidney transplant patients, because of its susceptibility to Lee Sister bacteria infection. Urogenital surgery increases the chance of infection with Listeria. Chemotherapy and the original underlying diseases can induce immune dysfunction.