核转录因子(NF-κB)作为一种分布广泛的真核细胞转录因子,能与B细胞免疫球蛋白κ轻链基因的增强子κB序列特异性结合,还与炎症、创伤、免疫反应、细胞增殖与凋亡密切相关。近年来研究表明,NF-κB还与大肠癌肿瘤细胞的凋亡、耐药等有关。现对NF-κB的信号转导机制及其与大肠癌的关系作一综述。 As a widely distributed eukaryotic transcription factor, NF-κB specifically binds to the enhancer κB sequence of the B cell immunoglobulin κ light chain gene. It also binds to inflammation, trauma, immune response, Proliferation and apoptosis are closely related. In recent years, studies have shown that, NF-κB also with colorectal cancer cell apoptosis, resistance and so on. Now the signal transduction mechanism of NF-κB and its relationship with colorectal cancer are reviewed.