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目的评价大剂量维生素B2联合托吡酯预防偏头痛发作的效果及安全性。方法采用半随机对照研究,凡符合入选标准的患者按就诊号的奇、偶数随机分别进入试验组和对照组。试验组每次给予25 mg托吡酯(bid)、400 mg维生素B2(qd),连续服用60 d;对照组每次给予25 mg托吡酯(bid),连续服用60 d。观察治疗前后头痛发作频率、程度、持续时间的变化,评价预防效果。结果两组治疗后头痛发作频率、程度、持续时间均较治疗前有所改善(P<0.05);试验组经治疗,发作频率、持续时间的改善情况优于对照组,两者比较有统计学意义(P<0.05),两组均未发生严重的不良反应。结论大剂量维生素B2联合托吡酯预防偏头痛发作的效果及安全性良好。
Objective To evaluate the efficacy and safety of high-dose vitamin B2 combined with topiramate in preventing migraine attacks. Methods A semi-randomized controlled study was conducted. All patients meeting the inclusion criteria were randomly assigned to the experimental group and the control group according to the odd and even numbers of the visit number. The experimental group was given 25 mg of topiramate (bid) and 400 mg of vitamin B2 (qd) once a day for 60 days. The control group was given 25 mg of topiramate once daily for 60 days. Observe the frequency of headache attack before and after treatment, degree, duration of change, evaluation of prevention. Results The frequency, degree and duration of headache attack after treatment in both groups were significantly improved compared with that before treatment (P <0.05). The improvement of treatment frequency, duration of seizure and treatment group were better than the control group Significance (P <0.05), no serious side effects occurred in both groups. Conclusion The effect and safety of high-dose vitamin B2 combined with topiramate in prevention of migraine attacks are good.