Objective:Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans(M.fragrans)(nutmeg) and Morinda citrifolia(M.citrifolia)(mengkudu) oils. Methods:The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essenlial oils were delermined by beta-carotene/ linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.Results:The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil.The nutmeg oil effectively inhibited the oxidation of linoleic acid with(88.68±0.1)%while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is(69.44±0.4)%.The nutmeg oil and mengkudu oil showed reducing power with an EC_(50) value of 181.4μg/mL and 3 043.0μg/mL,respectively.The anliangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC_(50) of 77.64μg/mL comparing to mengkudu oil which exhibits IC_(50) of 109.30μg/mL.Conclusion:Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs. Objective: To investigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia) (mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. antioxidant activities of both essenlial oils were delermined by beta-carotene / linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil effectively inhibited the oxidation of linoleic acid with (88.68 ± 0.1)% of the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44 ± 0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg / mL and 3 043.0 μg / mL, respectively. an an activity of nutmeg oil showed significant antiangiogenic activity with IC 50 7.64 μg / mL comparing to mengkudu oil which exhibits IC 50 (50) of 109.30 μg / mL. Conlusion: Bioactive compound (s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.