系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种侵犯多系统、多器官临床表现复杂多样的自身免疫性疾病[1]。其主要免疫学特征是由于机体细胞和体液免疫功能紊乱产生多种自身抗体,形成免疫复合物引起组织器官的损伤而致病。因此寻找高敏感性、高特异性的自身抗体对SLE的早期诊断、早期治疗有重要的意义[2]。随着生物化学和免疫学技术的发展, Systemic lupus erythematosus (SLE) is a complex and diverse autoimmune disease that affects multiple systems and multiple organs [1]. Its main immunological feature is due to the body cells and humoral immune dysfunction produce a variety of autoantibodies, the formation of immune complexes cause tissue and organ damage caused by disease. Therefore, looking for high sensitivity, high specificity of autoantibodies on the early diagnosis of SLE, early treatment has important significance [2]. With the development of biochemistry and immunology technology,