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为探讨一氧化氮(NO)和肿瘤坏死因子(TNF-a)在类风湿关节炎(RA)中的作用,检测了50例RA患者的关节液及血清中NO浓度和血清中TNF-a浓度,与30名健康人血清中NO浓度进行比较。结果表明,RA组血清中NO浓度(0.46±0.07μmol/L)高于正常对照的2倍,差异有非常显著意义(P<0.01)。而且关节液中NO浓度(0.95±0.17μmol/L)也显著高于血清中浓度(P<0.01)。RA组血清中TNF-a(65.12±2.46μg/L)与正常对照相比差异有显著意义(P<0.01),而且RA组血清中NO浓度与TNF-a成正相关(r=0.16,P<0.05)。结论:TNF-a和NO在RA的发病中起到一定作用。TNF-a在体内可以使巨噬细胞产生大量的NO,关节液中增加的NO随关节液循环进入血液中,造成身体其他部位的损伤。
To investigate the role of nitric oxide (NO) and tumor necrosis factor (TNF-a) in rheumatoid arthritis (RA), the concentrations of NO and serum TNF-a in synovial fluid and serum of 50 RA patients , Compared with 30 healthy human serum NO concentration. The results showed that the concentration of NO in serum of RA group (0.46 ± 0.07μmol / L) was two times higher than that of normal control group, the difference was significant (P <0.01). Moreover, NO concentration in synovial fluid (0.95 ± 0.17μmol / L) was also significantly higher than that in serum (P <0.01). The level of serum TNF-a (65.12 ± 2.46μg / L) in RA group was significantly lower than that in normal control group (P <0.01), and NO level in RA group was positively correlated with TNF-α (r = 0.16, 0.05). Conclusion: TNF-a and NO play a role in the pathogenesis of RA. TNF-a in the body can make macrophages produce large amounts of NO, increased NO in synovial fluid circulating into the bloodstream with the body, causing damage to other parts of the body.