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目的探讨持续气道正压通气治疗肥胖低通气综合征（ＯＨＳ）的疗效。方法用ＣＰＡＰ（经鼻持续气道正压通气）及ＢｉＰＡＰ（双水平气道正压通气）呼吸机分别对２１例及１４例肥胖低通气综合征患者治疗２个月，比较治疗前后的呼吸紊乱指数（ＡＨＩ）、低通气指数（ＨＩ）、体块指数（ＢＭＩ）、４％的血氧饱和度降低次数（ＯＤＩ４）以及最低血氧饱和度（ｍｉｎＳａＯ２），并将ＢＭＩ与ＡＨＩ、ＨＩ及ｍｉｎＳａＯ２作相关性分析。结果肥胖低通气患者治疗后ＡＨＩ、ＨＩ、ＢＭＩ、ＯＤＩ４、ｍｉｎＳａＯ２均有明显改善（Ｐ＜００５）；而ＢＭＩ与ＨＩ、及ｍｉｎＳａＯ２的相关性检验无显著性（相关系数分别为ｒ＝０．０３４６８和ｒ＝０．０５５８１，Ｐ＞００５），提示单纯降低ＢＭＩ并不能有效地改善ＨＩ及ｍｉｎＳａＯ２。结论持续气道正压通气是治疗ＯＨＳ一种无创、有效的措施，且能在短期内明显改善临床症状，提高生活质量。
Objective To investigate the efficacy of continuous positive airway pressure ventilation in the treatment of obesity-hypoventilation syndrome (OHS). Methods Twenty-one and 14 patients with obesity-hypoventilation syndrome were treated with CPAP (nasal continuous positive airway pressure) and BiPAP (biphasic positive airway pressure) ventilator for 2 months respectively. The respiratory disorders before and after treatment were compared AHI, HI, BMI, ODI4 and minSaO2 of 4%, and BMI with AHI, HI and minSaO2 Make correlation analysis. Results The AHI, HI, BMI, ODI4 and minSaO2 in obese patients with obesity were significantly improved (P <005), while the correlation between BMI and HI and minSaO2 was not significant (correlation coefficient was r = 0 .03468 and r = 0.05581, P> 005), suggesting that simply lowering BMI did not improve HI and minSaO2 effectively. Conclusion Continuous positive airway pressure ventilation is a noninvasive and effective measure for OHS, and can significantly improve clinical symptoms and improve quality of life in a short period of time.