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To study the early diagnosis of serum glutathione S-transferase(GST)in ethanol-induced hepatotoxicity in mice.The result showed that the activities of hepatic glutathione peroxidase,glutathione reductase and superoxide dismutase(SOD)were significantly changed in ethanol(5.7 and 11.4g·kg -1 ig)-treated mice.Serum GST activity and hepatic MDA formation were also remarkably increased.However,there were no serum alanine aminotransferase(ALT) and liver pathological changes.In addition,antioxidants sodium ferulate(100mg·kg -1 ig,qd×10) and allimin(10mg·kg -1 ig,qd×10)treatment could reverse the higher activities of serum GST in ethanol(11.4g·kg -1 )-treated mice.These results suggested that serum GST activity is more sensitive than serum ALT in acute ethanol-induced hepatotoxicity.
To study the early diagnosis of serum glutathione S-transferase (GST) in ethanol-induced hepatotoxicity in mice. The result showed the activities of hepatic glutathione peroxidase, glutathione reductase and superoxide dismutase (SOD) were significantly changed in ethanol (5.7 and 11.4 g · kg -1 ig) -treated mice. Serum GST activity and hepatic MDA formation were also remarkably increased. Having had no serum alanine aminotransferase (ALT) and liver pathological changes. In addition, antioxidants sodium ferulate (100 mg · kg - 1 ig, qd × 10) and allimin (10 mg · kg -1 ig, qd × 10) treatment could reverse the higher activities of serum GST in ethanol (11.4 g · kg -1) -treated mice.These results suggested that serum GST activity is more sensitive than serum ALT in acute ethanol-induced hepatotoxicity.