Wegener 肉芽肿是罕见病,1931年 Klinger 及1936年 Wegener 首先描述。国内仅有少数病例报道。本病主要特点:(1)呼吸道坏死性肉芽肿损害,(2)全身弥散性灶性坏死性血管炎,(3)灶性坏死性肾小球肾炎。现报告一例如下。王×,男,36岁,住院号165045,因鼻塞、鼻涕带脓血,蛋白尿,全身关节肌肉痛2年于1980年6月2日入院。病初检查发现“鼻中隔溃疡易出血”,半年内活检三次示“粘膜慢性炎症”,用抗菌素治疗无效。病后14个月腰痛,脸、脚浮肿,不规则发热。入院前半月频咳气促,四肢皮肤散发皮疹。入院时患者呈慢性贫血 Wegener’s granulomatosis is a rare condition, first described by Klinger in 1931 and Wegener in 1936. Only a few domestic cases reported. The main features of the disease: (1) respiratory necrosis granulomatous lesions, (2) systemic diffuse focal necrotizing vasculitis, (3) focal necrotizing glomerulonephritis. Here is an example of the report. King ×, male, 36 years old, hospital number 165045, due to nasal congestion, nasal discharge with purulent blood, proteinuria, systemic joint muscle pain 2 years in June 2, 1980 admission. Disease early examination found that “nasal septal ulcer hemorrhage”, within six months of biopsy showed three “chronic mucosal inflammation”, with antibiotic treatment ineffective. 14 months after the illness low back pain, face, feet swollen, irregular fever. Hyperactivity cough in the first half of admission, skin exudes rash. Patients were chronic anemia on admission