论文部分内容阅读
为研究饮食性肥胖鼠下丘脑单胺类神经递质含量和肥胖的关系，以及耐力训练对其影响，选用４４只雄性离乳ＳＤ大鼠，３６只饲以高脂饲料，其余为对照。１０周后，高脂组１８只鼠确定为饮食诱发肥胖大鼠（ＤＩＯ），其中８只用跑台进行耐力训练（６５－７５％Ｖｏ２ｍａｘ）。所有大鼠继续饲养８周后处死。所有大鼠记录能量摄入，以高效液相色谱法测定下丘脑单胺类神经递质。结果如下：肥胖鼠不存在多食，下丘脑ＮＥ、ＤＡ和５－ＨＴ增加。耐力运动可以提高下丘脑ＮＥ含量。提示，下丘脑单胺类神经递质的改变可能与高脂饮食的能量密度高有关。耐力训练可有效地降低饮食性肥胖鼠体脂，但并不是通过下丘脑单胺类神经递质的调节作用实现的。
In order to study the relationship between monoamine neurotransmitter content and obesity in hypothalamus of diet-induced obese mice and the effects of endurance training on them, 44 male SD rats were selected, 36 were fed with high-fat diet and the rest as control. After 10 weeks, 18 rats in the high-fat group were identified as diet-induced obese rats (DIO), of which 8 were endurance-trained (65-75% Vo2max) with treadmill. All rats were sacrificed 8 weeks after sacrifice. All rats were recorded energy intake, high performance liquid chromatography determination of monoamine neurotransmitter in the hypothalamus. The results are as follows: obese rats do not eat more, hypothalamic NE, DA and 5-HT increased. Endurance exercise can increase the NE content of the hypothalamus. Tip, changes in hypothalamic monoamine neurotransmitters may be related to the high energy density of high-fat diet. Endurance training can effectively reduce body fat in diet-obese mice, but not through modulation of hypothalamic monoamine neurotransmitters.