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目的:观察茵芪肝复颗粒联合抗病毒治疗对慢性乙型肝炎患者肝功能和脂代谢的影响。方法:选择2015年12月至2016年12月广州市第一人民医院肝病科收治的慢性乙型肝炎患者108例为临床研究资料,患者入院后编号,单号为对照组54例,双号为联合组54例。对照组进行抗病毒治疗,联合组进行茵芪肝复颗粒与抗病毒治疗。治疗6个月,治疗结束后比较两组疗效。结果:治疗后,联合组总有效率明显高于对照组,两组差异具有统计学意义(P<0.05)。两组患者谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBIL)水平相较于治疗前均有明显下降,且联合组下降幅度均高于对照组,差异有统计学意义(P<0.05)。两组患者三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和血清总胆固醇(TC)水平均有明显上升,且联合组上升程度均高于对照组,差异有统计学意义(P<0.05)。结论:芪茵肝复颗粒联合抗病毒治疗可以显著改善患者肝功能和脂代谢。
Objective: To observe the effect of Yinqifughu granules combined with antiviral therapy on liver function and lipid metabolism in chronic hepatitis B patients. Methods: From December 2015 to December 2016, 108 cases of chronic hepatitis B patients admitted to Department of Hepatology, Guangzhou First People’s Hospital were enrolled in this study. The patients were admitted to hospital after the admission number, the single number was 54 cases in the control group, Combined group of 54 cases. The control group was treated with antiviral therapy, and the combination group was treated with Yinqi Ganghuai granule and antiviral therapy. Treatment for 6 months, after treatment, the two groups were compared. Results: After treatment, the total effective rate in the combined group was significantly higher than that in the control group, the difference between the two groups was statistically significant (P <0.05). The levels of ALT, AST and total bilirubin (TBIL) in both groups were significantly lower than those before treatment, and the decreasing rates in the combination group were higher than those in the control group, the difference was statistically significant (P <0.05). The levels of triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and serum total cholesterol (TC) were significantly increased in both groups, and the increase in the combination group was higher than that in the control group There was statistical significance (P <0.05). Conclusion: Qi Yan Gan Fu granules combined with antiviral therapy can significantly improve liver function and lipid metabolism.