红细胞毒性药物引起的非免疫性溶血性贫血(下称溶贫)通常只发生于葡萄糖6—磷酸脱氢酶(G6PD)缺乏者。这一并发症以往多见于抗疟药、磺胺类和氯霉素的应用中。目前发现,在少数情况下,β—内酰胺抗生素也可以引起纯红细胞性再障。从文献报道看,青霉素和头孢噻吩是较常引起这一并发症的两种抗生素,前者是少数几种能和组织蛋白牢固结合的药物之一。体内、外试验证明,青霉素可与正常的 Non-immune hemolytic anemia (hereinafter referred to as “poor-solubility”) caused by erythrocyte toxic drugs usually occurs only in the absence of glucose 6-phosphate dehydrogenase (G6PD). This complication in the past more common in the application of antimalarial drugs, sulfonamides and chloramphenicol. It has been found that in a few cases, β-lactam antibiotics can also cause pure red cell aplasia. As reported in the literature, penicillin and cefalotin are the two most common antibiotics that cause this complication. The former is one of the few drugs that bind strongly to tissue proteins. In vitro and in vivo tests show that penicillin can be used with normal