大鼠灌服抗生育剂量的雷公藤多甙（ＧＴＷ）并不影响血清中抑制素水平，但用体外培养大鼠曲细精管方法观察不同剂量的ＧＴＷ对支持细胞功能的影响，发现低剂量ＧＴＷ并不影响支持细胞合成与分泌抑制素功能，也不影响其对ＦＳＨ的应激反应，但大剂量ＧＴＷ可明显抑制支持细胞的基础分化与应激反应。因此，认为大剂量的ＧＴＷ对细胞有明显的毒性作用。 Rats fed with anti-fertility dose of tripterygium glycosides (GTW) did not affect serum inhibin levels, but in vitro cultured seminiferous tubules of different doses of GTW on the function of supporting cells found that low-dose GTW did not affect the function of supporting cell synthesis and secretion of inhibin, nor did it affect the stress response to FSH, but high-dose GTW significantly inhibited the basal differentiation and stress response of supporting cells. Therefore, it is considered that high-dose GTW has a significant cytotoxic effect on cells.