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缓释制剂系指用药后能在较长时间内持续释放药物以达到长效作用的制剂 ,其中药物释放主要是一级速度过程。控释制剂系指药物能在预定的时间内自动以预定速度释放 ,使血药浓度长时间恒定维持在有效浓度范围内制剂 ,其中药物主要以零级或接近零级速度释放。1 发展历史缓释、控释
Sustained-release preparation refers to the preparation that can release drugs for a long time after treatment to achieve long-term effect, wherein the drug release is mainly a first-rate process. Controlled release formulation refers to the drug can be automatically released at a predetermined speed within a predetermined period of time to maintain a constant blood concentration for a long time in the effective concentration range of the formulation, wherein the drug is released mainly at the zero or near zero speed. 1 history of development of sustained release, controlled release