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为了保证临床用药安全有效,国内外学者对乌头类主要毒性成分——双酯类生物碱含量测定方法进行了大量工作。目前,常用的有1990版《中国药典》规定的异羟肟酸铁比色法,1985版《中国药典》规定的薄层层析法,薄层扫描法和高效液相法等。但以上方法都需要一定的仪器设备和熟练专业技术人员,比色法还存在着操作步骤复杂,涉及化学试剂药品多,时间长,非专业人员测定误差大等问题。本文介绍的快速限量法具有简便、快速、半定量特点,尤其适合广大基层饮片厂,药房和药材经销部门需要,可与现版药
In order to ensure the safe and effective clinical use of drugs, domestic and foreign scholars have done a lot of work on the determination of the main toxic components of Aconitum - double ester alkaloids. At present, commonly used is the hydrophobate hydroxamate colorimetric method stipulated in the 1990 edition of the Chinese Pharmacopoeia, the thin layer chromatography, the thin layer scanning method, and the high-performance liquid method as stipulated in the 1985 edition of the Chinese Pharmacopoeia. However, the above methods all require certain equipments and skilled professional technicians. The colorimetric method still has the problems of complicated operation procedures, many chemical reagents and drugs, long time, and large non-professionals’ measurement errors. The fast limit method introduced in this article is simple, rapid, and semi-quantitative, and is especially suitable for the needs of grassroots-level decoction plants, pharmacies and medicinal materials distribution departments, and can be used with current versions of drugs.