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目的 :探讨非小细胞肺癌患者放疗前后血清中CEA、CYFRA21-1及NSE的水平变化情况及相关疗效评价。方法 :分析2013年1月-2014年12月在我院接受治疗的非小细胞肺癌患者的临床资料,列为观察组,同时选取在我院进行健康检查的人群作为对照组。结果 :观察组患者化疗后血清中CEA、AFP、NSE和CYFRA21-1含量明显高于对照组,差异具有统计学意义,观察组患者放疗后血清中CEA、NSE和CYFRA21-1含量低于放疗前指标水平,差异具有统计学意义;放疗后PR患者血清中CEA、NSE和CYFRA21-1水平显著低于放疗前,差异具有统计学意义。放疗后PD患者血清中CEA CYFRA21-1水平明显高于放疗前,差异具有统计学意义;由ROC曲线分析可知,当CEA的界值为5.91 ng/m L时对晚期NSCLC的诊断敏感性为76.19%,特异性为93.94%,诊断价值优于NSE和CYFRA21-1。结论 :血清中CEA、CYFRA21-1及NSE的水平可作为评价放疗疗效的特异性指标,具有一定临床实用价值。
Objective: To investigate the changes of serum CEA, CYFRA21-1 and NSE in patients with non-small cell lung cancer before and after radiotherapy and the related curative effect evaluation. Methods: The clinical data of patients with non-small cell lung cancer treated in our hospital from January 2013 to December 2014 were analyzed and classified as observation group. At the same time, we selected the people in our hospital for health examination as the control group. Results: The serum levels of CEA, AFP, NSE and CYFRA21-1 in the observation group were significantly higher than those in the control group, the difference was statistically significant. The levels of CEA, NSE and CYFRA21-1 in the observation group were lower than those before the radiotherapy The levels of CEA, NSE and CYFRA21-1 in patients with PR after radiotherapy were significantly lower than those before radiotherapy, and the difference was statistically significant. The serum levels of CEA CYFRA21-1 in patients with PD after radiotherapy were significantly higher than those before radiotherapy. The ROC curve analysis showed that the sensitivity of CEA to diagnosis of advanced NSCLC was 76.19 when the cutoff value of CEA was 5.91 ng / m L %, Specificity of 93.94%, diagnostic value is better than NSE and CYFRA21-1. Conclusion: The serum levels of CEA, CYFRA21-1 and NSE can be used as a specific index to evaluate the curative effect of radiotherapy and have certain clinical value.