论文部分内容阅读
目的了解男性外勤交警人群血尿酸水平,探讨其高血尿酸与心血管危险因素及其聚集性之间的关系。方法采用方便抽样方法,以1 039名广州市男性外勤交警人群为研究对象,进行问卷调查、体格检查和实验室检查。根据血尿酸水平是否偏高(>420.00μmol/L)将研究对象分为高血尿酸组和对照组。结果男性外勤交警人群血尿酸水平中位数为431.00μmol/L,高血尿酸检出率为56.3%。高血尿酸组人群外勤警龄、收缩压、舒张压和血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、肌酐的水平均高于对照组(P<0.01),高密度脂蛋白胆固醇水平低于对照组(P<0.01)。多因素Logistic回归分析显示,调整混杂因素年龄和饮酒后,超重与肥胖、高TG和高TC男性外勤交警罹患高血尿酸的风险均高于正常者(P<0.05),比值比(OR)及其95%可信区间(CI)分别为2.347(1.772~3.109)、2.040(1.517~2.743)和1.431(1.080~1.896);男性外勤交警罹患高血尿酸的风险均随外勤警龄和血肌酐水平的增加而升高(P<0.05),OR及其95%CI分别为1.028(1.004~1.054)和1.048(1.033~1.062)。男性外勤交警人群中高血尿酸者所占比例随着心血管危险因素的增多而增多(P<0.01)。男性外勤交警人群有1、2、3、4及5个以上的心血管危险因素时罹患高血尿酸的风险分别为无心血管危险因素个体的1.583、2.351、4.657、2.865和13.576倍(P<0.05)。结论男性外勤交警人群罹患高血尿酸的风险与心血管危险因素密切相关,其风险随心血管危险因素聚集而增加。
Objective To understand the level of serum uric acid in male field traffic policemen and to explore the relationship between hyperuricemia and cardiovascular risk factors and their aggregation. Methods A sample of 1039 male field traffic police in Guangzhou was selected as the research object by convenient sampling method, and questionnaires, physical examination and laboratory tests were conducted. According to whether the level of serum uric acid is high (> 420.00μmol / L), the subjects are divided into hyperuricemia group and control group. Results The median of serum uric acid level in male field traffic police was 431.00μmol / L and the rate of hyperuricemia was 56.3%. Serum levels of SBP, SBP, TG, TC, LDL-C and creatinine in hypertensive group were higher than those in control group (P <0.01), high-density lipoprotein cholesterol levels were lower than the control group (P <0.01). Multivariate Logistic regression analysis showed that the risk of hyperuricemia in overweight and obesity, high TG and high TC male field traffic police were higher than those in control group (P <0.05), odds ratio (OR) and The 95% confidence intervals (CI) were 2.347 (1.772-3.109), 2.040 (1.517-2.7743) and 1.431 (1.080-1.896), respectively. The risk of hyperuricemia in field service traffic policemen was higher than that of field service and serum creatinine (P <0.05). OR and 95% CI were 1.028 (1.004-1.0554) and 1.048 (1.033-1.062), respectively. The proportion of high blood uric acid in male field traffic police increased with the increase of cardiovascular risk factors (P <0.01). The risk of developing hyperuricemia in male field traffic police population with 1, 2, 3, 4 and more than 5 cardiovascular risk factors were 1.583, 2.351, 4.657, 2.865 and 13.576 times higher than those without cardiovascular risk factors (P <0.05 ). Conclusions The risk of hyperuricemia in male field traffic policemen is closely related to cardiovascular risk factors. The risk increases with the accumulation of cardiovascular risk factors.