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背景与目的:中国结直肠癌发病率逐年上升,其中直肠癌所占比例超过50%,尤以中低位直肠癌多见。男性患者由于盆腔的解剖特点,在治疗方式的选择、保肛比例及预后方面均有其自身的特点。本研究旨在探讨男性直肠癌患者临床病理特征及其与预后的关系。方法:选择年龄、病程、首发症状、肿瘤部位、肿瘤大小、肿瘤占肠腔周径比例、肿瘤大体类型、组织类型、肠壁浸润深度、Dukes@分期、淋巴结转移位置及术式等12项临床病理指标,用单因素和多因素分析的方法研究其对384例男性直肠癌患者预后的影响。结果:单因素分析显示,肿瘤部位、肿瘤大体类型、组织类型、肿瘤浸润肠壁深度、淋巴结转移位置及Dukes@分期为影响预后的因素。Cox比例危险回归模型多因素分析显示,仅组织类型及淋巴结转移位置为男性直肠癌患者预后的独立影响因素。结论:组织类型及淋巴结转移位置为男性直肠癌预后的独立影响因素。
BACKGROUND & OBJECTIVE: The incidence of colorectal cancer in China has been increasing year by year, with the proportion of rectal cancer exceeding 50%, especially in low and middle rectal cancer. Male patients due to pelvic anatomy, the choice of treatment, anal stenosis and prognosis have their own characteristics. The purpose of this study was to investigate the clinicopathological features of male patients with rectal cancer and its relationship with prognosis. Methods: Twelve clinical trials including age, course of disease, initial symptom, location of tumor, tumor size, ratio of tumor to perimeter of intestine, gross tumor type, histological type, depth of intestinal wall invasion, Dukes stage, Pathological indicators, univariate and multivariate analysis of 384 male patients with rectal cancer prognosis. Results: Univariate analysis showed that tumor location, gross tumor type, tissue type, depth of tumor infiltrating bowel wall, lymph node metastasis and Dukes stage were the prognostic factors. Cox proportional hazard regression model multivariate analysis showed that only the type of tissue and location of lymph node metastasis of male patients with rectal cancer prognostic independent factors. Conclusion: The type of tissue and location of lymph node metastasis are independent prognostic factors for male rectal cancer.