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目的:探讨丽水地区男性尖锐湿疣(CA)患者皮损人乳头瘤病毒(HPV)基因分型情况。方法:采用Hybri Max医用核酸分子快速杂交系统对丽水地区110例男性CA患者(年龄16~65岁)的疣体组织样本进行HPV基因分型检测。结果:110例患者中107例HPV检测阳性,HPV感染率97.27%,单一型感染76例(71.03%),多重感染31例(28.97%),感染高峰年龄段集中在21~40岁。检测出HPV基因型14种,高危型为HPV16、53、52、33、CP8304、58、51、45、66、68、59,感染率44.85%;低危型为HPV11、6、19(43),感染率为93.45%。结论:丽水地区男性CA患者HPV感染以低危型为主,高危型及多重感染率高。
Objective: To investigate the genotyping of human papillomavirus (HPV) lesions in male genital warts (CA) in Lishui area. Methods: HPV genotyping was performed on wart tissue samples from 110 male patients with CA (aged 16-65 years) in Lishui Prefecture by using Hybri Max rapid hybridization system. Results: Of the 110 patients, 107 were positive for HPV, 97.27% for HPV infection, 76 (71.03%) for single infection, and 31 (28.97%) for multiple infections. The peak infection age ranged from 21 to 40 years. HPV genotypes were detected in 14 species, high-risk HPV16,53,52,33, CP8304,58,51,45,66,68,59, the infection rate was 44.85%; low-risk HPV11,6,19 (43) , The infection rate was 93.45%. Conclusion: HPV infection in male patients with CA in Lishui area is mainly at low risk type, while high risk type and multiple infection rate are high.