论文部分内容阅读
目的探讨环孢素A能否有效治疗肾病综合征,以及不同病理或临床类型肾病综合征应用环孢素A的疗效差别,为临床上肾病综合征治疗方案的选择提供指导。方法通过MEDLINE、ACPJournalClub、AHRQ计算机检索系统检索1987～2003年的相关文献,采用加权百分率法进行荟萃分析。结果应用环孢素A治疗,不论在治疗期间还是在停止治疗12～21个月后,其有效率都比不含环孢素A的其他治疗方案高,且在治疗期间不同病理或临床类型的缓解率不同微小病变型较局灶节段硬化型高,激素依赖型较激素抵抗型为高,但停止治疗6～10个月后不同病理或临床类型的缓解率无明显差别。结论环孢素A能有效治疗肾病综合征且无病理或临床类型的选择性。
Objective To investigate whether cyclosporine A can effectively treat nephrotic syndrome and the difference of curative effect of cyclosporine A in different pathological or clinical nephrotic syndromes and provide guidance for the choice of treatment options for nephrotic syndrome in clinic. Methods MEDLINE, ACPJournalClub and AHRQ computer retrieval system were used to search the relevant literature from 1987 to 2003, and the weighted percentage method was used for meta-analysis. Results Cyclosporin A treatment, both during treatment and 12 to 21 months after discontinuation of treatment, was more effective than other regimens without cyclosporin A, and the different pathologies or types of treatment during treatment Lesions with different lesser degree of micro-lesions than the focal sclerosis, hormone-dependent hormone-resistant type is high, but stopped treatment of 6 to 10 months after the different pathological or clinical types of remission rate was no significant difference. Conclusion Cyclosporine A is effective in treating nephrotic syndrome with no pathological or clinical selectivity.