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目的测定代谢综合征(MS)患者血清同型半胱氨酸(homocysteine,HCY)、胱抑素C(cystatin,CysC)的水平,探讨二者对代谢综合征患者的临床意义。方法随机收集代谢综合征患者血清30例,对照组血清32例。测定两组血清HCY、CysC的水平,并分析代谢综合征组HCY与CysC的相关性。结果代谢综合征组的血清HCY、CysC水平均较对照组升高且有统计学意义(P<0.05),并且代谢综合征组血清CysC与HCY呈正相关(r=0.652,P<0.01)。结论血清HCY和CysC水平均为可反映代谢综合征病情的较为敏感、准确、可靠的指标,两者联合检测对代谢综合征患者在诊断、治疗、病情监测上有一定的临床意义。
Objective To determine the levels of serum homocysteine (HCY) and cystatin C (CysC) in patients with metabolic syndrome (MS) and to explore their clinical significance in patients with metabolic syndrome. Methods 30 cases of patients with metabolic syndrome were randomly collected, and 32 cases of serum of control group. The levels of serum HCY and CysC in the two groups were determined, and the correlation between HCY and CysC in the metabolic syndrome group was analyzed. Results The levels of serum HCY and CysC in the metabolic syndrome group were significantly higher than those in the control group (P <0.05), and the serum CysC was positively correlated with HCY in the metabolic syndrome group (r = 0.652, P <0.01). Conclusions The levels of serum HCY and CysC are sensitive, accurate and reliable indexes that can reflect the condition of metabolic syndrome. The combined detection of them has some clinical significance in the diagnosis, treatment and disease monitoring of patients with metabolic syndrome.