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测定60例脑卒中病人血浆皮质醇、甲状腺激素值,结果:(1)与正常组比较脑卒中组皮质醇、rT_3显著升高(P<0.01),T_3显著降低(P<0.01),出血组皮质醇、T_3变化尤为明显,而 T_4、TSH 无明显变化(P>0.05)。(2)皮质醇、甲状腺激素变化和病灶范围有密切关系。病灶越大,变化越显著。皮质醇值随出血量和梗塞面积的增加而升高,呈正相关。当出血量>30ml、梗塞面积>20cm~2时和 T_3、T_3/rT_3值呈负相关,与 rT_3值呈正相关。(3)出血量影响皮质醇生理节律:小量出血,生理节律存在;中量出血,生理节律消失;大量出血,生理节律逆转。(4)皮质醇、T_3/rT_3值可作为判断病情、估计预后的指标。
Plasma cortisol and thyroid hormones were measured in 60 stroke patients. Results: (1) The levels of cortisol, rT_3 and T_3 in stroke group were significantly lower than those in normal group (P <0.01) Cortisol, T_3 change is particularly obvious, while T_4, TSH no significant change (P> 0.05). (2) Cortisol, thyroid hormone changes and the extent of lesions are closely related. The larger the lesion, the more significant changes. Cortisol value with the amount of bleeding and increased infarct size was positively correlated. When the amount of bleeding> 30ml, infarction area> 20cm ~ 2 and T_3, T_3 / rT_3 value was negatively correlated with the rT_3 value was positively correlated. (3) The amount of bleeding affected cortisol physiological rhythm: a small amount of bleeding, circadian rhythms exist; in the amount of bleeding, circadian rhythms disappear; a large number of bleeding, circadian rhythm reversal. (4) cortisol, T_3 / rT_3 value can be used as an indicator of prognosis.