氧化是老年性白内障产生的主要原因。正常晶体中谷胱甘肽(GSH)含量较高,而在白内障晶体中含量很低,说明GSH对保持晶体的透明起了一定的作用。本文用实验的方法增加晶体上皮细胞内GSH的含量,了解在此情况下细胞受氧化损害后细胞膜的改变及细胞内ATP含量的变化,得出:受H_2O_2的作用,细胞膜上的Na-K-ATP酶受到抑制,细胞膜通透性增加,细胞内ATP含量下降。细胞内升高的GSH不能防止或减轻外界氧化物质对晶体上皮细胞的氧化损害。 Oxidation is the main cause of senile cataract. Normal crystals of glutathione (GSH) content is high, but low levels in cataract crystals, indicating that GSH to maintain the transparency of the crystal played a role. In this paper, the experimental method to increase the content of GSH in the lens epithelial cells to understand the changes in cell membrane oxidative damage and ATP content in this case, that: by the role of H_2O_2, cell membrane Na-K- ATPase was inhibited, cell membrane permeability increased, decreased intracellular ATP content. Increased intracellular GSH does not prevent or reduce the oxidative damage of crystalline oxide to the epithelial cells.