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目的了解抗高血压药的临床应用模式,并促进其合理用药。方法利用医院信息系统药房管理子系统,对2008年11月14日—11月18日某综合性医院门诊患者含抗高血压药的处方进行回顾性分析。合理性标准为药品说明书、国内外循证医学研究结果、药物代谢酶学和2007年欧洲高血压治疗指南。结果该院的抗高血压药治疗应用总体较为合理,较好地符合治疗指南。极少量处方在用法用量和合并用药方面的合理性值得商榷。结论临床医生和药师应遵循药物治疗指南,注意鉴别潜在的相互作用,做好患者用药教育和抗高血药药物治疗达标管理。应用药动学原理,可以有效指导临床合理选药。对于多重用药患者可以加强药物治疗监测,必要时换用替代药品等。
Objective To understand the clinical application of antihypertensive drugs and to promote their rational use of drugs. Methods The hospital information system pharmacy management subsystem was used to retrospectively analyze the prescriptions of antihypertensives in a general hospital outpatient department from November 14, 2008 to November 18, 2008. Rationality criteria for the drug instructions, evidence-based medical research at home and abroad, drug metabolism enzyme and 2007 European guidelines for the treatment of hypertension. Results The hospital’s antihypertensive drug treatment is generally more reasonable and good, in line with the treatment guidelines. Very few prescriptions in the amount of usage and the rationality of the merger is questionable. Conclusion Clinicians and pharmacists should follow the guidelines for drug treatment, pay attention to identify potential interactions, good patient education and anti-hyperlipidemic drug treatment compliance management. Application of pharmacokinetic principles, can effectively guide the clinical rational drug selection. For multiple drug users can strengthen drug treatment monitoring, if necessary, to replace alternative drugs.