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目的探究急诊救治双硫仑样反应特征和规律。方法对近年我院收治的32例双硫仑样反应患者急诊救治的临床资料进行回顾性分析。结果引起双硫仑样反应的药物以头孢菌素居多,占78.1%(25/32),多为用药后当天饮酒后所致,占62.5%(20/32),临床症状及体征以皮肤潮红、心悸、烦躁、头晕头痛居多,所有患者均经综合急诊对症支持治疗后,于30min~180min内得以缓解,无死亡病例。结论双硫仑样反应的临床症状表现较复杂,且病情较危重,经积极治疗后,临床预后良好。
Objective To investigate the characteristics and regularities of emergency treatment of disulfiram-like reaction. Methods The clinical data of 32 cases treated with disulfiram-like reaction in our hospital in recent years were analyzed retrospectively. Results The drug which caused disulfiram-like reaction was mostly cephalosporin, accounting for 78.1% (25/32), mostly after drinking on the day after medication, accounting for 62.5% (20/32). The clinical symptoms and signs were as follows: , Heart palpitations, irritability, dizziness and headache mostly, all patients were treated with comprehensive emergency symptomatic treatment, within 30min ~ 180min to be relieved, no deaths. Conclusion The clinical symptoms of disulfiram-like reaction are complicated and the condition is more serious. After active treatment, the clinical prognosis is good.