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采用PCR-RFLP技术,对100例正常个体和100例T2DM患者的TCF7L2基因rs290487多态性进行检测,结果:在病例组和对照组TCF7L2的多态性位点rs290487等位基因的频数分布差异无统计学意义(χ2=0.251,P>0.05);基因型的频数分布差异无统计学意义(χ2=0.248,P>0.05)。Logistic回归显示,与CC基因型比较,携带突变等位基因T的基因型(CT和TT)并没有改变患T2DM的风险,该多态性与T2DM的易感性关联无统计学意义。结论:在中国济南地区人群的TCF7L2基因rs290487多态性可能与T2DM无关
The PCR-RFLP technique was used to detect rs290487 polymorphism of TCF7L2 gene in 100 normal individuals and 100 T2DM patients. Results: There was no significant difference in frequency distribution of rs290487 alleles among the TCF7L2 polymorphism loci in case group and control group Statistical significance (χ2 = 0.251, P> 0.05). There was no significant difference in the frequency distribution of genotypes (χ2 = 0.248, P> 0.05). Logistic regression showed that the genotypes (CT and TT) carrying the mutant allele T did not change the risk of T2DM compared with the CC genotype. The association between the polymorphism and the susceptibility to T2DM was not statistically significant. Conclusion: Polymorphism of rs290487 in TCF7L2 gene may not be related to T2DM in Jinan of China