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目的:探讨2型糖尿病患者的内脏脂肪容积和胰岛素抵抗(IR)的关系。方法:对60例2型糖尿病患者,按照内脏脂肪容积,分为非内脏肥胖组和内脏肥胖组,均采用CT在L4-5水平扫描,进行皮下及内脏脂肪容积测定;采用稳态模式评估法(HOMA)计算胰岛素抵抗指数,测定相关的人体指标、空腹血生化检查。结果:肥胖组内脏脂肪容积平均值为132.10cm2,非肥胖组内脏脂肪容积平均值为72.32cm2;内脏肥胖组比非肥胖组甘油三酯水平增高;内脏肥胖组IR平均值为2.60,非肥胖组IR平均值为1.22,两组差异有显著意义。内脏脂肪和皮下脂肪与2型糖尿病胰岛素抵抗显著相关,其中内脏脂肪是IR的最大影响因素。结论:内脏脂肪容积是2型糖尿病胰岛素抵抗的独立影响因子。
Objective: To investigate the relationship between visceral fat volume and insulin resistance (IR) in type 2 diabetic patients. Methods: Sixty patients with type 2 diabetes mellitus were divided into non-visceral obesity group and visceral obesity group according to the visceral fat volume. CT scanning was performed at L4-5 level to determine subcutaneous and visceral fat volume. (HOMA) calculated insulin resistance index, determination of relevant human indicators, fasting blood biochemical tests. Results: The average visceral fat volume in obesity group was 132.10 cm 2, the average visceral fat volume in non-obese group was 72.32 cm 2, the triglyceride level in visceral obesity group was higher than that in non-obese group, the average IR was 2.60 in visceral obesity group, IR average of 1.22, the difference between the two groups was significant. Visceral fat and subcutaneous fat were significantly associated with insulin resistance in type 2 diabetes, with visceral fat being the most significant contributor to IR. Conclusions: Visceral fat volume is an independent factor of insulin resistance in type 2 diabetes mellitus.