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本实验将２４只昆明雄性大白鼠随机均分为三组，即正常对照组，发热高峰组及发热恢复组，给发热组动物腹腔注射大肠杆菌内毒素（ＥＴ）。结果发现：发热高峰组动物与正常对照组比较血清Ｃｕ含量明显）曾加（Ｐ＜０．０５），血清Ｆｅ含量明显减少（Ｐ＜０．００１），Ｚｎ、Ｍｇ含量虽也有减少，但无显著性差异，恢复组动物与对照组比较血清Ｃｕ、Ｚｎ、Ｆｅ、Ｍｇ含量均无明显变化。丘脑下部组织Ｃｕ、Ｚｎ、Ｆｅ和Ｍｇ在发热高峰组与对照组比较无明显变化，发热恢复组动物与对照组比较，丘及下部Ｃｕ、Ｚｎ含量明显增加（Ｐ＜０．０１）。作者认为：大鼠ＥＴ发热时血清微量元素Ｃｕ、ｚｎ、Ｆｅ、Ｍｇ含量与丘脑下部的含量变化无关，血清Ｃｕ含量增加，Ｆｅ含量减少可能参与动物发热时的急性期反应，与机体发热时的防御反应有关。
In this experiment, 24 Kunming male rats were randomly divided into three groups: normal control group, fever peak group and fever recovery group. The animals in fever group were injected intraperitoneally with E. coli endotoxin (ET). The results showed that the content of Cu in serum was significantly increased (P <0.05) and the content of Fe in serum in the peak fever group was significantly lower than that in the normal control group (P <0.001), while the content of Zn and Mg was decreased There was no significant difference in the contents of Cu, Zn, Fe and Mg in the recovery group compared with the control group. The contents of Cu, Zn, Fe and Mg in the subthalamic tissues did not change significantly in the peak fever group compared with the control group. The contents of Cu and Zn in the lower part of the hypothalamus and the control group were significantly increased compared with the control group (P <0.01). The author thinks: the contents of Cu, Zn, Fe and Mg in serum of rats after ET fever have nothing to do with the changes of the content of the lower part of the hypothalamus, the content of Cu in the serum increases and the content of Fe decreases, which may be involved in the acute phase reaction when the animals are experiencing fever. Defense reaction related.