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目的了解德宏州、西双版纳州的6种少数民族G6PD缺乏症的现况,为其防治提供科学依据。方法西双版纳州采用G6PD荧光斑点试验,德宏州采用改良G6PD/6PGD定量比值法。统计学处理:采用SPSS13/PEMS3.软件,计数资料用χ2检验,并进行多因素Logistic分析。结果 1.不同年龄G6PD缺乏率各年龄组无明显差异;2.不同性别G6PD缺乏有明显差异,男童6.3%,女童1.9%,男童明显高于女童;3.不同地区同一民族比较:版纳州傣族阳性率为2.5%,德宏州傣族阳性率为6.8%,德宏州明显高于版纳州;4.不同民族比较:G6PD缺乏率以德昂族居首,其后依次为:阿昌族7.1%、景颇族、汉族及其他民族5.0%,傣族4.0%、布朗族0.4%。两两比较各民族之间差异有显著意义P<0.001;5.多因素分析:显示不同州有差异,同一州不同县市也有差异,都是危险因素。结论 1.进行人群筛检以发现携带者,从而降低G6PD的发生率;2.地区影响大于民族影响。
Objective To understand the status of G6PD deficiency in 6 ethnic minorities in Dehong Prefecture and Xishuangbanna Prefecture and provide a scientific basis for their prevention and treatment. Methods G6PD fluorescent speckle test was used in Xishuangbanna prefecture, and modified G6PD / 6PGD quantitative method was used in Dehong prefecture. Statistical analysis: using SPSS13 / PEMS3 software, counting data using χ2 test, and multivariate Logistic analysis. Results 1. The G6PD deficiency rate at different ages showed no significant difference among all age groups. 2. There was significant difference in G6PD deficiency rate among different sexes, with 6.3% for boys and 1.9% for girls, and boys were significantly higher than girls. 3. Comparison of the same nationalities in different regions: The positive rate of Dai nationality is 2.5%, the deyang Dai positive rate is 6.8%, Dehong state is significantly higher than the Banna state; 4. Comparison of different ethnic groups: G6PD lack rate in the De An dominance, followed by: Achang 7.1 %, Jingpo, Han and other nationalities 5.0%, Dai 4.0%, Blang 0.4%. P <0.001; 5.Multivariate analysis showed that there are differences among different states and different counties and cities in the same state are all risk factors. Conclusions 1. Conduct population screening to find carriers, thereby reducing the incidence of G6PD; 2. Regional influence is greater than the national impact.