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目的:探索地屈孕酮用于治疗早期先兆流产的效果。方法:在深圳市龙岗区人民医院2015年7月至2016年7月收治的早期先兆流产患者中随机抽取出80例作为本研究的观察对象,以抽签法进行分组,分为观察组和对照组,其中观察组患者采用地屈孕酮治疗,对照组患者采用黄体酮治疗,对比分析两组患者的保胎成功率、血β–人绒毛膜促性腺激素(β–HCG)水平、不良反应发生率等指标。结果:观察组患者的保胎成功率90.0%略高于对照组的85.0%,差异无统计学意义(P>0.05);观察组保胎成功患者治疗2周后的血β–HCG水平明显高于对照组,差异具有统计学意义(P<0.05);观察组患者用药不良反应发生率5.0%低于对照组的20.0%,差异具有统计学意义(P<0.05);观察组保胎成功患者的治疗时间比对照组短,差异具有统计学意义(P<0.05)。结论:在早期先兆流产中采用地屈孕酮治疗保胎效果好,且用药安全性高,有助于缩短治疗疗程。
Objective: To explore the effect of dydrogesterone on the treatment of early threatened abortion. Methods: 80 cases of early threatened abortion patients were randomly selected from the People’s Hospital of Longgang District, Shenzhen from July 2015 to July 2016. The patients were divided into observation group and control group , In which the patients in the observation group were treated with dydrogesterone and the patients in the control group were treated with progesterone. The success rate of miscarriage and the level of β-HCG in both groups were compared and analyzed. The adverse reactions occurred Rate and other indicators. Results: The success rate of miscarriage in observation group was slightly higher than that in control group (90.0%) (85.0%), the difference was not statistically significant (P> 0.05); the level of serum β-HCG was significantly higher in observation group after two weeks of treatment (P <0.05). The incidence of adverse reactions in the observation group was lower than 5.0% in the control group (P <0.05), and the difference was statistically significant (P <0.05) Treatment time shorter than the control group, the difference was statistically significant (P <0.05). Conclusion: The use of dydrogesterone in early threatened abortion has a good effect on tocolysis and high drug safety, which can help to shorten the course of treatment.