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目的探究低剂量沙利度胺联合常规化疗治疗多发性骨髓瘤临床治疗效果及不良反应。方法对2008年10月至2010年12月我院接收并确诊的78例多发性骨髓瘤患者用沙利度胺联合常规化疗来治疗,观察记录患者症状的改变,记录治疗效果和不良反应。结果 78例患者中,19例完全缓解,28例部分缓解,17例进步,总有效率82.1%。不良反应有皮疹、便秘、嗜睡、感染及周围神经炎等,均可耐受。结论低剂量沙利度胺联合常规化疗治疗多发性骨髓瘤临床治疗效果较好,不良反应较小,值得在临床推广。
Objective To investigate the clinical effects and adverse reactions of low-dose thalidomide combined with conventional chemotherapy in the treatment of multiple myeloma. Methods From October 2008 to December 2010, 78 patients with multiple myeloma received and diagnosed in our hospital were treated with thalidomide combined with conventional chemotherapy. The changes of symptoms were recorded and the therapeutic effects and adverse reactions were recorded. Results Of the 78 patients, 19 were completely relieved, 28 were partially relieved, and 17 were improved. The total effective rate was 82.1%. Adverse reactions are rash, constipation, lethargy, infection and peripheral neuritis, can be tolerated. Conclusion Low-dose thalidomide combined with conventional chemotherapy in the treatment of multiple myeloma clinical treatment is better, less adverse reactions, it is worth in the clinical promotion.