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不同于单基因遗传疾病,人类常见疾病如心脑血管疾病、代谢性疾病、精神行为异常、肿瘤等均是由多种环境和遗传因素共同导致的复杂疾病。随着人类基因组计划(human genome project,HGP)和国际人类基因组单体型图计划(the International Hap Map Project,Hap Map)的相继完成,高通量基因分型技术的发展,使得在大规模人群中开展全基因组关联研究成为现实[1]。
Different from single-gene genetic diseases, common diseases such as cardiovascular and cerebrovascular diseases, metabolic diseases, mental and behavioral disorders, tumors and the like are complex diseases caused by a variety of environmental and genetic factors. With the success of the human genome project (HGP) and the International Hap Map Project (Hap Map), the development of high-throughput genotyping technologies has led to the development of large-scale population In carrying out genome-wide association studies become a reality [1].