论文部分内容阅读
目的探讨miR-375在胃癌中的表达及其与胃癌临床病理特征之间的关系。方法选取苏州大学附属第一医院2008年12月至2009年4月间经手术切除的原发性胃癌标本及癌旁组织标本各50例,采用实时荧光定量PCR技术检测miR-375的表达,分析其与胃癌临床病理特征之间的关系。结果 miR-375在胃癌组织中的表达相对于癌旁组织明显下调(P<0.05),miR-375的表达与胃癌TNM分期、浸润深度和淋巴结转移无关(P>0.05)。结论 miR-375在胃癌组织中的表达降低,在胃癌发生发展中可能起到一定的作用。
Objective To investigate the expression of miR-375 in gastric cancer and its relationship with clinicopathological features of gastric cancer. Methods Fifty cases of primary gastric cancer specimens and adjacent non-cancerous tissue specimens from the First Affiliated Hospital of Soochow University from December 2008 to April 2009 were selected. Real-time fluorescence quantitative PCR was used to detect the expression of miR-375. Its relationship with clinicopathological features of gastric cancer. Results The expression of miR-375 in gastric cancer tissues was significantly lower than that in paracancer tissues (P <0.05). The expression of miR-375 was not associated with TNM stage, depth of invasion and lymph node metastasis (P> 0.05). Conclusions miR-375 is down-regulated in gastric cancer and may play a role in the development of gastric cancer.