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目的探讨儿童中幽门螺杆菌(Hp)感染与缺铁性贫血(IDA)的相关性。方法以因慢性腹痛而行胃镜检查及Hp检测的60例患儿为观察对象,根据检查结果分为Hp阳性慢性胃炎组、Hp阴性慢性胃炎组及Hp阳性胃部镜下无损害组三组。所有病例均检测血红蛋白(Hb)、平均红细胞体积(MCV)、血清铁(SI)、血清铁蛋白(SF)、总铁结合力(TIBC)等IDA指标。比较三组之间的IDA指标和IDA伴发率。结果三组病例IDA指标两两比较显示,Hp阴性慢性胃炎组分别和Hp阳性慢性胃炎组、Hp阳性胃部镜下无损害组的IDA指标比较差异均有统计学意义(P<0.01,P<0.05),而Hp阳性慢性胃炎组与Hp阳性胃部镜下无损害组之间的比较差异则无统计学意义(P>0.05)。Hp阴性慢性胃炎的IDA伴发率均明显低于Hp阳性慢性胃炎组和阳性胃部镜下无损害组(P<0.05),Hp阳性慢性胃炎组与Hp阳性胃部镜下无损害组之间的IDA伴发率差异无统计学意义(P>0.05)。结论儿童幽门螺杆菌感染与缺铁性盆血两者之间具有显著的相关性,其相关性较慢性胃炎更为密切。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and iron deficiency anemia (IDA) in children. Methods Sixty children with gastroscopy and Hp detected by chronic abdominal pain were observed. According to the test results, they were divided into three groups: Hp positive chronic gastritis group, Hp negative chronic gastritis group and Hp positive gastroscope nondestructive group. All cases were detected IDA indexes such as Hb, MCV, SI, SF, TIBC. The IDA and IDA comparisons between the three groups were compared. Results The pairwise comparison of IDA indexes of three groups of patients showed that there was significant difference in IDA between Hp-negative chronic gastritis group and Hp-positive chronic gastritis group and Hp-positive gastroscope without damage group (P <0.01, P < 0.05). However, there was no significant difference between Hp positive chronic gastritis group and Hp positive gastroscope without damage group (P> 0.05). Hp-negative chronic gastritis with IDA incidence were significantly lower than those in Hp-positive chronic gastritis group and positive gastroscope without damage group (P <0.05), between Hp-positive chronic gastritis group and Hp-positive gastroscope without damage group IDA with no significant difference (P> 0.05). Conclusion There is a significant correlation between Helicobacter pylori infection and iron-deficient basin blood in children, which is more closely related to chronic gastritis.