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目的分析探讨促甲状腺激素受体在甲状腺癌中的表达及其临床意义,为甲状腺癌的患者治疗提供理论支持和科学指导。方法 50例甲状腺癌的患者为研究组,同期50例体检健康者为对照组。将两组采集的甲状腺组织进行HE染色观察,进行免疫组织化学检测促甲状腺激素受体在甲状腺组织中的表达情况。结果两组患者的甲状腺激素受体的着色深浅和部位有偏差,研究组患者的着色比对照组体检者浅,其表达的部位都位于细胞膜的基地侧。在阳性率表达方面,研究组患者的阳性表达率为68.0%,对照组体检者的阳性表达率为100.0%,两组比较差异具有统计学意义(P<0.05)。结论甲状腺激素受体在正常的甲状腺组织中的表达率较高,同时甲状腺激素受体会随着甲状腺组织分化程度的降低其表达率明显下降,为临床上甲状腺癌患者治疗提供了重要的数据参考。
Objective To investigate the expression and clinical significance of thyroid stimulating hormone receptor in thyroid cancer and to provide theoretical support and scientific guidance for the treatment of patients with thyroid cancer. Methods 50 cases of thyroid cancer patients for the study group, 50 cases of healthy subjects for the same period as the control group. The thyroid tissues collected from both groups were observed by HE staining and the expression of thyroid stimulating hormone receptor in thyroid tissue was detected by immunohistochemistry. Results The shading depth and location of the thyroid hormone receptors in both groups were deviated. The study group patients were lighter than those in the control group, and all the sites were located on the base side of the cell membrane. The positive expression rate of the study group was 68.0%, while the positive rate of the control group was 100.0%. The difference between the two groups was statistically significant (P <0.05). Conclusions The expression of thyroid hormone receptor in normal thyroid tissue is high. At the same time, the thyroid hormone receptor expression decreases with the decrease of thyroid tissue differentiation, which provides important data for the treatment of thyroid cancer patients .