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目的比较雷贝拉唑与奥美拉唑治疗老年反流性食管炎患者的临床效果及安全性。方法选取老年反流性食管炎患者120例,按照临床医治时不同方案,将行雷贝拉唑治疗患者60例作为观察组,将行奥美拉唑治疗患者60例作为对照组,比较2组临床效果及安全性。结果 2组治疗后血清胃动素及胃泌素水平均高于治疗前,且观察组高于对照组;观察组治疗后胸痛、反流及烧心症状评分均低于对照组,差异均有统计学意义(P<0.05)。2组治疗后口干、腹泻等不良反应无明显差异(P>0.05)。结论老年反流性食管炎患者行雷贝拉唑治疗可优化血清胃动素、胃泌素水平,改善患者临床症状,且不良反应少。
Objective To compare the clinical efficacy and safety of rabeprazole and omeprazole in the treatment of elderly patients with reflux esophagitis. Methods A total of 120 elderly patients with reflux esophagitis were enrolled in this study. According to different plans of clinical treatment, 60 patients treated with rabeprazole as observation group and 60 patients treated with omeprazole as control group. Clinical effect and safety. Results The levels of serum motilin and gastrin in the two groups were significantly higher than those before treatment, and the observation group was higher than the control group. The scores of chest pain, reflux and heartburn in the observation group were lower than those in the control group Significance (P <0.05). There was no significant difference in adverse reactions such as dry mouth and diarrhea between the two groups after treatment (P> 0.05). Conclusion The treatment of elderly patients with reflux esophagitis in rabeprazole treatment can optimize serum motilin and gastrin levels and improve the clinical symptoms of patients with less adverse reactions.