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目的为了提高难溶性药物西洛他唑的溶出度,制备西洛他唑/介孔碳固体分散体。方法以表面活性剂F127为胶束模板,以酚醛树脂的乙醇溶液为碳源制备介孔碳,选用西洛他唑作为模型药,采用吸附平衡挥干法和溶液吸附法载药制得西洛他唑固体分散体,采用扫描电镜、氮气吸附-脱附和热分析手段表征介孔碳及西洛他唑/介孔碳固体分散体的性质。结果制得的介孔碳孔径均一,其孔径主要集中在6.3 nm,载体的比表面积为1 255.4 m2.g-1,孔容为1.441 cm3.g-1,载体的载药质量可高达33.1%,溶出数据表明西洛他唑/介孔碳固体分散体的溶出速率与累积溶出度与药物西洛他唑相比均有了显著提高。结论介孔碳有望成为能提高难溶性药物溶出度的优良载体。
Objective To improve the dissolution of cilostazol, a poorly soluble drug, and prepare cilostazol / mesoporous carbon solid dispersion. Methods The surfactant F127 was used as a micellar template to prepare mesoporous carbon with phenolic resin as the carbon source. Cilostazol was selected as a model drug. The drug was absorbed by equilibrium adsorption and adsorption The solid dispersion of tazobactam was characterized by scanning electron microscopy, nitrogen adsorption-desorption and thermal analysis to characterize the properties of mesoporous carbon and cilostazol / mesoporous carbon solid dispersions. As a result, the pore diameter of the mesoporous carbon was uniform, the pore diameter was mainly 6.3 nm, the specific surface area of the carrier was 1 255.4 m2.g-1, the pore volume was 1.441 cm3.g-1, and the carrier drug loading was as high as 33.1% , Dissolution data show that the cilostazol / mesoporous carbon solid dispersion dissolution rate and cumulative dissolution and drug cilostazol have increased significantly. Conclusion Mesoporous carbon is expected to be an excellent carrier for enhancing the dissolution of poorly soluble drugs.